Dienemann H, Hoffmann H, Mewes A, Müller C, Schildberg F W
Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.
Zentralbl Chir. 1993;118(9):539-42.
From 1982 through April 1992, 192 patients underwent extended resection for non-small cell carcinoma of the lung (NSCLC) invading the chest wall (n = 52) or the mediastinum (n = 140). Complete resection of the tumor was possible in 81 (58%) patients with invasion of mediastinum and in 34 (65%) patients with invasion of the chest wall. The operative mortality was 9%, respiratory complications causing most of the postoperative morbidity and mortality. Incomplete resection was associated with poor prognosis. The mean survival of these patients was 10 month. The 5 year actuarial survival rate of patients having curative resection was 20%. In these patients the presence of lymphatic metastases significantly reduced survival, with a 3 year actuarial survival rate of 40% of patients with No disease, and 30% or 5% for those with N1 or N2 disease, respectively. In conclusion, extended resection for advanced NSCLC offers a significant chance for long-term survival in the absence of N2 lymphatic metastases. In the presence of N2 metastases and poor overall prognosis however, reasonable palliation is the primary goal of surgical management.
从1982年至1992年4月,192例患者因非小细胞肺癌(NSCLC)侵犯胸壁(n = 52)或纵隔(n = 140)而接受扩大切除术。81例(58%)纵隔受侵患者和34例(65%)胸壁受侵患者实现了肿瘤的完全切除。手术死亡率为9%,呼吸并发症是术后发病和死亡的主要原因。不完全切除与预后不良相关。这些患者的平均生存期为10个月。接受根治性切除患者的5年精算生存率为20%。在这些患者中,存在淋巴转移显著降低了生存率,无疾病患者的3年精算生存率为40%,N1或N2疾病患者的3年精算生存率分别为30%或5%。总之,对于晚期NSCLC,在不存在N2淋巴转移的情况下,扩大切除术提供了显著的长期生存机会。然而,在存在N2转移且总体预后较差的情况下,合理的姑息治疗是手术管理的主要目标。