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[支气管癌扩大切除术:并发症及远期疗效]

[Extended resections in bronchial cancer: complications and late results].

作者信息

Dienemann H, Hoffmann H, Mewes A, Müller C, Schildberg F W

机构信息

Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Ludwig-Maximilians-Universität München.

出版信息

Zentralbl Chir. 1993;118(9):539-42.

PMID:8237150
Abstract

From 1982 through April 1992, 192 patients underwent extended resection for non-small cell carcinoma of the lung (NSCLC) invading the chest wall (n = 52) or the mediastinum (n = 140). Complete resection of the tumor was possible in 81 (58%) patients with invasion of mediastinum and in 34 (65%) patients with invasion of the chest wall. The operative mortality was 9%, respiratory complications causing most of the postoperative morbidity and mortality. Incomplete resection was associated with poor prognosis. The mean survival of these patients was 10 month. The 5 year actuarial survival rate of patients having curative resection was 20%. In these patients the presence of lymphatic metastases significantly reduced survival, with a 3 year actuarial survival rate of 40% of patients with No disease, and 30% or 5% for those with N1 or N2 disease, respectively. In conclusion, extended resection for advanced NSCLC offers a significant chance for long-term survival in the absence of N2 lymphatic metastases. In the presence of N2 metastases and poor overall prognosis however, reasonable palliation is the primary goal of surgical management.

摘要

从1982年至1992年4月,192例患者因非小细胞肺癌(NSCLC)侵犯胸壁(n = 52)或纵隔(n = 140)而接受扩大切除术。81例(58%)纵隔受侵患者和34例(65%)胸壁受侵患者实现了肿瘤的完全切除。手术死亡率为9%,呼吸并发症是术后发病和死亡的主要原因。不完全切除与预后不良相关。这些患者的平均生存期为10个月。接受根治性切除患者的5年精算生存率为20%。在这些患者中,存在淋巴转移显著降低了生存率,无疾病患者的3年精算生存率为40%,N1或N2疾病患者的3年精算生存率分别为30%或5%。总之,对于晚期NSCLC,在不存在N2淋巴转移的情况下,扩大切除术提供了显著的长期生存机会。然而,在存在N2转移且总体预后较差的情况下,合理的姑息治疗是手术管理的主要目标。

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