在小鼠获得性免疫缺陷综合征期间，膳食酒精对隐孢子虫抵抗力的抑制作用。

Suppression by dietary alcohol of resistance to Cryptosporidium during murine acquired immune deficiency syndrome.

作者信息

Alak J I, Shahbazian M, Huang D, Wang Y, Darban H, Watson R R, Jenkins E M

机构信息

Tuskegee University, AL.

出版信息

Adv Exp Med Biol. 1993;335:175-9. doi: 10.1007/978-1-4615-2980-4_25.

DOI:10.1007/978-1-4615-2980-4_25

PMID:8237593

Abstract

Significant immunological changes occur following LP-BM5 murine leukemia retrovirus infection as well as chronic alcohol consumption. Retrovirus infection which has proceeded to murine AIDS permitted persistent Cryptosporidium infection, while non-retrovirus infected mice were resistant. Dietary alcohol provided until the day before parasite challenge did not affect resistance in controls, but increased the numbers of oocysts in the feces of retrovirus suppressed mice. Mortality was significant in retrovirus infected mice, and exacerbated slightly by dietary ethanol, while all controls survived parasite challenge. The retrovirus infected mice had greatly reduced numbers of intestinal CD4+ T helper cells and IgA+ B cells, which may explain their loss of intestinal resistance. Clearly, the severely immunosuppressed animals with murine AIDS were more sensitive to alcohol consumption than uninfected controls. This suggests that alcohol can synergize with murine retrovirus infection to exacerbate loss of resistance to an opportunistic pathogen common in human AIDS patients.

摘要

感染LP - BM5鼠白血病逆转录病毒以及长期饮酒后会发生显著的免疫变化。进展为鼠类艾滋病的逆转录病毒感染会导致隐孢子虫持续感染，而未感染逆转录病毒的小鼠具有抗性。在寄生虫攻击前一天提供的膳食酒精对对照组的抗性没有影响，但增加了逆转录病毒感染小鼠粪便中的卵囊数量。逆转录病毒感染的小鼠死亡率很高，膳食乙醇会使其略有加剧，而所有对照组在寄生虫攻击中存活下来。逆转录病毒感染的小鼠肠道CD4 + T辅助细胞和IgA + B细胞数量大幅减少，这可能解释了它们肠道抗性的丧失。显然，患有鼠类艾滋病的严重免疫抑制动物比未感染的对照组对饮酒更敏感。这表明酒精可与鼠类逆转录病毒感染协同作用，加剧对人类艾滋病患者常见的机会性病原体抗性的丧失。