Fagiolo E
Acta Haematol. 1976;56(2):97-106. doi: 10.1159/000207925.
Platelet and leukocyte counts and leukocytotoxic and platelet antibodies were studied in 32 patients with autoimmune hemolytic anemia (AHA). Leukopenia was present in 59.4%, thrombocytopenia in 59.4% and leuko-thrombocytopenia in 40.5% of the cases. Specific antibodies for granulocytes were found in 81.3%, platelet antibodies in 90.6%. The AHA, leukopenia and thrombocytopenia generally presented a dissociated evolution and a different response to immunosuppressive treatment. The leukopenia of 2 and the thrombocytopenia of 6 patients appeared at variable time intervals after the AHA or the detection of leukocyte and platelet antibodies. Thrombocytopenic purpura was present in 6 patients, and in 2 of these since infancy. AHA may thus be a comples autoimmune syndrome that may involve leukocytes and platelets as well as erythrocytes, with synthesis of autoantibodies specific for different blood cells.
对32例自身免疫性溶血性贫血（AHA）患者进行了血小板和白细胞计数以及白细胞毒性和血小板抗体研究。59.4%的病例存在白细胞减少，59.4%存在血小板减少，40.5%存在白细胞血小板减少。81.3%的患者发现粒细胞特异性抗体，90.6%发现血小板抗体。AHA、白细胞减少和血小板减少通常呈现分离性演变以及对免疫抑制治疗的不同反应。2例患者的白细胞减少和6例患者的血小板减少在AHA或检测到白细胞和血小板抗体后的不同时间间隔出现。6例患者出现血小板减少性紫癜，其中2例自婴儿期起即患病。因此，AHA可能是一种复杂的自身免疫综合征，可能累及白细胞、血小板以及红细胞，并合成针对不同血细胞的自身抗体。
