Bock J E, Gaede P, Trolle D
Acta Obstet Gynecol Scand Suppl. 1976;53:14-9. doi: 10.3109/00016347609156440.
Determination of human placental lactogen hormone (HPL) was performed in 346 serum samples from 59 rhesus isoimmunized pregnant women. In all cases of fetal death-either intrauterine or in the first seven days after birth-we find a high level of HPL in maternal serum several weeks before death. All patients with normal HPL concentrations in the maternal serum, and who were treated by intrauterine transfusions, had surviving infants. If the indication for intrauterine transfusion is combined with an elevated HPL level in materal serum one must weigh the risk of the procedure against the poor prognosis for the fetus before deciding whether to intervene. Serum concentrations of human chorionic gonadotropin (HCG) and progesterone were of no clinical use, but we find a correlation between progesterone and HPL differing from the same correlation found in normal and diabetic pregnancies. A possible explanation is discussed in relation to the endoplasmic reticulum in the syncytiotrophoblast.
对59例恒河猴血型免疫的孕妇的346份血清样本进行了人胎盘催乳素（HPL）测定。在所有胎儿死亡的病例中——无论是宫内死亡还是出生后前七天内死亡——我们发现在死亡前几周母体血清中HPL水平较高。所有母体血清中HPL浓度正常且接受宫内输血治疗的患者，其婴儿均存活。如果宫内输血的指征与母体血清中HPL水平升高同时存在，那么在决定是否进行干预之前，必须权衡该操作的风险与胎儿的不良预后。人绒毛膜促性腺激素（HCG）和孕酮的血清浓度无临床应用价值，但我们发现孕酮与HPL之间的相关性与正常和糖尿病妊娠中的相同相关性不同。结合合体滋养层内质网对可能的解释进行了讨论。
