Owen J, Maher J E, Hauth J C, Goldenberg R L, Parker C R
Department of Obstetrics and Gynecology, University of Alabama at Birmingham 35233-7333.
Am J Obstet Gynecol. 1993 Oct;169(4):907-11. doi: 10.1016/0002-9378(93)90025-e.
Our purpose was to determine if the maternal administration of low-dose (60 mg) aspirin from 24 weeks' gestation until delivery is associated with significant changes in longitudinal umbilical artery Doppler index values.
Healthy, young nulliparous women with singleton gestations who were enrolled in a double-blind trial of low-dose aspirin for preeclampsia prevention underwent prerandomization and monthly postrandomization continuous-wave umbilical artery Doppler evaluations. The systolic-to-diastolic ratio and the resistance index were determined at each examination. Compliance with the medical regimen was assessed by pill counts and measurement of maternal serum thromboxane B2 levels.
The prerandomization Doppler index values were similar between the two randomization groups in the 538 (aspirin 266, placebo 272) patients studied. We found no significant differences with univariate comparisons and multiple linear regression modeling in the postrandomization Doppler index values (p = 0.21 to 0.96). No differences were found when patients were assessed by randomization assignment group (intent to treat) or by biochemical evidence for compliance and absence of crossover with maternal serum thromboxane B2 levels.
The use of low-dose aspirin from 24 weeks' gestation until delivery does not significantly affect umbilical artery Doppler index values.
我们的目的是确定从妊娠24周直至分娩期间，母体服用低剂量（60毫克）阿司匹林是否与脐动脉多普勒指数纵向值的显著变化相关。
纳入一项预防子痫前期的低剂量阿司匹林双盲试验的健康、年轻未生育单胎妊娠女性，在随机分组前及随机分组后每月进行连续波脐动脉多普勒评估。每次检查时测定收缩压与舒张压比值及阻力指数。通过药丸计数和测定母体血清血栓素B2水平评估对治疗方案的依从性。
在研究的538例（阿司匹林组266例，安慰剂组272例）患者中，两个随机分组组在随机分组前的多普勒指数值相似。在随机分组后的多普勒指数值方面，我们通过单变量比较和多元线性回归模型未发现显著差异（p = 0.21至0.96）。当根据随机分组组（意向性分析）或根据母体血清血栓素B2水平的依从性生化证据及无交叉情况对患者进行评估时，未发现差异。
从妊娠24周直至分娩期间使用低剂量阿司匹林不会显著影响脐动脉多普勒指数值。
