Santoian E C, Thomas G, Angerio A D, Kot P A, Ramwell P W
Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, D.C.
Angiology. 1993 Nov;44(11):897-901. doi: 10.1177/000331979304401108.
Hydroxylamine is a natural product of cellular metabolism that possesses vasodilating properties similar to those of endothelium-derived relaxing factor (EDRF). In the rodent pulmonary circulation preconstricted with the endoperoxide analog U-46619, hydroxylamine relaxed the vasculature in a concentration-dependent manner. Blockade of the hydroxylamine vasodilator response by methylene blue indicated that the mechanism of vasorelaxation is similar to that of EDRF. In this preparation, hydroxylamine is a more potent vasodilator than nitroglycerin.
羟胺是细胞代谢的天然产物，具有与内皮源性舒张因子（EDRF）相似的血管舒张特性。在经内过氧化物类似物U - 46619预收缩的啮齿动物肺循环中，羟胺以浓度依赖性方式使血管舒张。亚甲蓝对羟胺血管舒张反应的阻断表明，血管舒张机制与EDRF相似。在该制剂中，羟胺是比硝酸甘油更强效的血管舒张剂。
