Martorell Aragonés A, Sanz Ortega J, Alvarez Angel V
Sección de Alergia, Hospital General Universitario, Universidad de Valencia.
An Esp Pediatr. 1993 Aug;39(2):116-24.
Airway responsiveness may be defined as the case with which airways narrow upon exposure to physical and chemical stimuli and drugs. Bronchial hyperresponsiveness reflects an excessive bronchoconstricting response to these stimuli. Although in part it may be genetically mediated, a number of environmental factors (allergens, viruses and contaminants) are also involved in increasing bronchial responsiveness through airway inflammation. We review the concept, etiology, pathogeny, clinical expression, diagnosis, preventative measures and treatment of bronchial hyperresponsiveness in pediatrics.
气道反应性可定义为气道在接触物理和化学刺激物及药物时变窄的情况。支气管高反应性反映了对这些刺激物过度的支气管收缩反应。尽管部分可能由遗传介导,但一些环境因素(过敏原、病毒和污染物)也通过气道炎症参与增加支气管反应性。我们综述了儿科支气管高反应性的概念、病因、发病机制、临床表现、诊断、预防措施及治疗。