处理全身性阿糖胞苷引起的点状角膜炎。
Handling punctate keratitis resulting from systemic cytarabine.
作者信息
Friedland S, Loya N, Shapiro A
机构信息
Department of Ophthalmology, Beilinson Medical Center, Petah Tiqva, Israel.
出版信息
Ann Ophthalmol. 1993 Aug;25(8):290-1.
PMID:8239322
Abstract
A young patient with acute myelogenous leukemia was treated with high-dose cytarabine (3.0 g/m2 every 12 hours). After five days of treatment, he developed severe photophobia and decreased visual acuity. On examination, progressive punctate keratitis was found. We discuss the mechanism of the cytarabine-induced corneal toxicity and the prophylactic use of topical corticosteroids.
摘要
一名患有急性髓性白血病的年轻患者接受了大剂量阿糖胞苷治疗（每12小时3.0 g/m²）。治疗五天后，他出现了严重的畏光和视力下降。检查发现有进行性点状角膜炎。我们讨论了阿糖胞苷诱导角膜毒性的机制以及局部皮质类固醇的预防性使用。
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