Tominaga T, Abe O, Izuo M, Isono K, Enomoto K, Nishi M, Fukami A, Muto T, Morioka Y, Watanabe H
Tokyo Metropolitan Komagome Hospital.
Gan To Kagaku Ryoho. 1993 Nov;20(14):2171-6.
We investigated possible correlations between estrogen receptor (ER) and prognostic factors in 3,789 patients with stage II or stage IIIa breast cancer in Japan. The patients with ER-positive tumors showed a significantly better prognosis in the 5-year survival rate and the 5-year disease-free survival rate compared with the patients with ER-negative-tumor. Positivities increased with increasing patient age, with increasing tumor size, and lowering degree of cell differentiation, and no relation was observed between the positivities and tumor sites, obesity index, and lymph-node metastasis.
我们调查了日本3789例II期或IIIa期乳腺癌患者雌激素受体（ER）与预后因素之间的可能相关性。与ER阴性肿瘤患者相比，ER阳性肿瘤患者的5年生存率和5年无病生存率显著更高。ER阳性率随患者年龄增加、肿瘤大小增加及细胞分化程度降低而升高，且未观察到ER阳性率与肿瘤部位、肥胖指数及淋巴结转移之间存在关联。
