Wallace J D, Thomas B J
Centre for Medical & Health Physics, Queensland University of Technology.
Australas Phys Eng Sci Med. 1993 Sep;16(3):118-24.
An in-vivo x-ray fluorescence (XRF) bone lead analyser, based on the Somervaille design, has been constructed and tested as the first step towards developing a deep bone lead analyser to expand the range of bone tissue available for assessment, to include more deep seated bones such as the femur & vertebrae. These bones represent a major component of the total body bone tissue and therefore the lead body burden. A new test analyser, constructed by modification to the basic design of a superficial bone analyser, has been used to investigate the feasibility of using changes in source-detector geometry and collimation to improve deep bone lead sensitivity for in-vivo measurement techniques. Initial results indicate that the relative detection sensitivity of the test analyser is approximately 6 times that of the Somervaille based system. The results of examination of a series of lead loaded plaster of paris phantoms (0 ppm - 360 ppm) confirmed there was good correlation (r = 0.996, p < 0.0005) between the measured ratio (lead X-rays/coherent scatter photons) and the lead concentrations using data from both XRF analyser systems.
一种基于索默维尔设计的体内X射线荧光（XRF）骨铅分析仪已被制造并测试，这是开发深部骨铅分析仪的第一步，目的是扩大可用于评估的骨组织范围，包括更多深部骨骼，如股骨和椎骨。这些骨骼是全身骨组织的主要组成部分，因此也是铅在体内的负荷量。通过对浅表骨分析仪基本设计进行改进而构建的新型测试分析仪，已用于研究改变源探测器几何形状和准直以提高体内测量技术对深部骨铅的灵敏度的可行性。初步结果表明，测试分析仪的相对检测灵敏度约为基于索默维尔设计的系统的6倍。对一系列含铅巴黎石膏模型（0 ppm - 360 ppm）的检测结果证实，使用来自两个XRF分析仪系统的数据，测量比值（铅X射线/相干散射光子）与铅浓度之间存在良好的相关性（r = 0.996，p < 0.0005）。
