丝裂原活化蛋白激酶（MAP激酶）、MAP激酶激酶和c-Mos刺激非洲爪蟾卵母细胞中的葡萄糖转运。
Mitogen-activated protein kinase (MAP kinase), MAP kinase kinase and c-Mos stimulate glucose transport in Xenopus oocytes.
作者信息
Merrall N W, Plevin R J, Stokoe D, Cohen P, Nebreda A R, Gould G W
机构信息
Department of Biochemistry, University of Glasgow, U.K.
出版信息
Biochem J. 1993 Oct 15;295 ( Pt 2)(Pt 2):351-5. doi: 10.1042/bj2950351.
Abstract
Mitogens and growth factors acutely stimulate glucose transport in all cells to supply energy for their growth and division, but little is known about the signalling mechanism by which these agonists promote sugar uptake. Here we show that the transport of deoxyglucose and 3-O-methylglucose into Xenopus laevis oocytes is stimulated about 2.5-fold when mitogen-activated protein kinase (MAP kinase) is microinjected into these oocytes. We also demonstrate that microinjection of the proto-oncogene product c-Mos (an activator of MAP kinase kinase, which activates MAP kinase in Xenopus oocytes), and purified MAP kinase kinase produce similar increases in deoxyglucose transport. Since the activation of MAP kinase is a general response to almost all mitogens and growth factors, we propose that one of its downstream effects is the stimulation of glucose-transport activity.
摘要
有丝分裂原和生长因子能迅速刺激所有细胞中的葡萄糖转运，为细胞生长和分裂提供能量，但对于这些激动剂促进糖摄取的信号传导机制却知之甚少。在此我们表明，当将丝裂原活化蛋白激酶（MAP激酶）显微注射到非洲爪蟾卵母细胞中时，脱氧葡萄糖和3 - O - 甲基葡萄糖进入这些卵母细胞的转运受到约2.5倍的刺激。我们还证明，显微注射原癌基因产物c - Mos（MAP激酶激酶的激活剂，在非洲爪蟾卵母细胞中激活MAP激酶）以及纯化的MAP激酶激酶，会使脱氧葡萄糖转运产生类似的增加。由于MAP激酶的激活是对几乎所有有丝分裂原和生长因子的普遍反应，我们提出其下游效应之一是刺激葡萄糖转运活性。
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本文引用的文献
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Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors.非洲爪蟾卵母细胞中肝型（GLUT2）和脑型（GLUT3）葡萄糖转运蛋白的动力学分析：底物特异性及转运抑制剂的作用
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Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase.鉴定胰岛素刺激的蛋白激酶-1为兔源的rskmo-2等同物。鉴定有丝分裂原激活的蛋白激酶激活过程中磷酸化的两个苏氨酸。
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