Raimondi L, Conforti L, Banchelli G, Ignesti G, Pirisino R, Buffoni F
Dept of Pharmacology, University of Florence, Italy.
Biochem Pharmacol. 1993 Oct 19;46(8):1369-76. doi: 10.1016/0006-2952(93)90101-2.
Histamine has previously been described as a possible substrate for the semicarbazide-sensitive amine oxidase activity (SSAO) of rat white adipose tissue (WAT). We report here on a histamine function in this tissue which concerns the activity of this deaminating system distinct from the classical diamine oxidase. Our results show that: (1) histamine plays a role in controlling rat adipose tissue lipolysis with the contribution of H1 and H2 receptors that participate in histamine lipolysis in an opposite way. Both H1 and H2 roles can be differentiated using selective agonists (2- and 4-methyl histamine) and antagonists (pyrilamine and cimetidine); (2) histamine might also control rat lipolysis induced by noradrenergic agonists; (3) the SSAO present in rat WAT controls histamine levels at the receptor sites as shown by the modification of histamine lipolytic potency obtained when inhibitors of this enzyme are used.
组胺此前被描述为大鼠白色脂肪组织（WAT）中氨基脲敏感胺氧化酶活性（SSAO）的一种可能底物。我们在此报告该组织中组胺的一种功能，此功能涉及这种脱氨基系统的活性，且不同于经典的二胺氧化酶。我们的结果表明：（1）组胺在控制大鼠脂肪组织脂解过程中发挥作用，其中H1和H2受体以相反方式参与组胺介导的脂解。使用选择性激动剂（2-甲基组胺和4-甲基组胺）和拮抗剂（吡苄明和西咪替丁）可区分H1和H2的作用；（2）组胺可能还控制去甲肾上腺素能激动剂诱导的大鼠脂解；（3）大鼠WAT中存在的SSAO可控制受体部位的组胺水平，这可通过使用该酶抑制剂时组胺脂解效力的改变得以证明。
