慢性苯氟雷司治疗对老年斯普拉格-道利大鼠肝脏碳水化合物代谢关键酶活性的影响。

Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats.

作者信息

Tielens A G, van den Heuvel J M, Schmitz M G, Geelen M J

机构信息

Laboratory of Veterinary Biochemistry, Utrecht University, The Netherlands.

出版信息

Biochem Pharmacol. 1993 Nov 2;46(9):1539-44. doi: 10.1016/0006-2952(93)90320-v.

DOI:10.1016/0006-2952(93)90320-v

PMID:8240408

Abstract

Chronic effects of benfluorex on some parameters of carbohydrate metabolism have been studied in 24-month-old Sprague-Dawley rats. Treatment once a day for 14 days with 25 mg benfluorex per kg body weight lowered body weight, decreased circulating insulin and resulted in an increase in hepatic glycogen. Measurement of the activities of several important regulatory enzymes of hepatic carbohydrate metabolism showed a significant decrease in the activities of phosphoenolpyruvate carboxykinase and glycogen phosphorylase. The activity of glucose-6-phosphatase, on the other hand, was slightly increased. Taken collectively, our data offer an explanation for the observed inhibition of hepatic glucose production by chronic benfluorex treatment in cases of hyperinsulinemia.

摘要

已在24月龄的斯普拉格-道利大鼠中研究了苯氟雷司对碳水化合物代谢某些参数的慢性影响。每天用每千克体重25毫克苯氟雷司治疗14天，会降低体重、减少循环胰岛素，并导致肝糖原增加。对肝脏碳水化合物代谢的几种重要调节酶活性的测量表明，磷酸烯醇丙酮酸羧激酶和糖原磷酸化酶的活性显著降低。另一方面，葡萄糖-6-磷酸酶的活性略有增加。总体而言，我们的数据为高胰岛素血症情况下慢性苯氟雷司治疗所观察到的肝脏葡萄糖生成抑制提供了解释。