Mesa-Valle C M, Moraleda-Lindez V, Craciunescu D, Alonso M P, Osuna A
Departamento de Parasitologia, Facultad de Ciencias, Universidad de Granada, Spain.
Arzneimittelforschung. 1993 Sep;43(9):1010-3.
The effects of 10 newly synthesized organometallic rhodium complexes (5 of Rh(I), 4 of Rh(III) and one of Rh(IV) complex salt) and 2 antimony (III) complexes against epimastigote forms of Trypanosoma cruzi and promastigote forms of Leishmania donovani have been studied in vitro. Of the 10 rhodium complexes tested three proved 100% efficient in inhibiting the growth of the epimastigote forms of T. cruzi while only one worked against the promastigote forms of L. donovani. The two antimony complexes inhibited the growth of L. donovani totally and were fairly successful against T. cruzi.
研究了10种新合成的有机金属铑配合物（5种铑（I）配合物、4种铑（III）配合物和1种铑（IV）配合物盐）以及2种锑（III）配合物对克氏锥虫无鞭毛体形式和杜氏利什曼原虫前鞭毛体形式的体外作用。在所测试的10种铑配合物中，有3种在抑制克氏锥虫无鞭毛体形式的生长方面证明有100%的效率，而只有1种对杜氏利什曼原虫前鞭毛体形式有效。这两种锑配合物完全抑制了杜氏利什曼原虫的生长，并且对克氏锥虫也相当有效。
