Kleiner D E, Stetler-Stevenson W G
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.
Curr Opin Cell Biol. 1993 Oct;5(5):891-7. doi: 10.1016/0955-0674(93)90040-w.
The degradation of the extracellular matrix is part of many pathological and physiological processes. Of the several proteases involved in extracellular matrix turnover, the plasmin/plasminogen activator system and the family of matrix metalloproteases have received the most attention. Recent investigations in the field of matrix metalloprotease biochemistry have focused on the functions of the various enzyme domains and their interactions with inhibitor domains. Research into physiological activation mechanisms has demonstrated a plasmin/plasminogen activator-metalloprotease cascade, as well as providing an initial characterization of cell surface associated metalloprotease activation.
细胞外基质的降解是许多病理和生理过程的一部分。在参与细胞外基质更新的几种蛋白酶中，纤溶酶/纤溶酶原激活剂系统和基质金属蛋白酶家族受到了最多关注。近期在基质金属蛋白酶生物化学领域的研究集中于各种酶结构域的功能及其与抑制剂结构域的相互作用。对生理激活机制的研究已证实存在纤溶酶/纤溶酶原激活剂-金属蛋白酶级联反应，并初步描述了细胞表面相关金属蛋白酶的激活过程。
