Fernández O, Romero F, Bravo M, Burgos D, Cabello M, González-Molina M
Servicio de Neurología, Hospital Regional de Málaga.
Neurologia. 1993 Oct;8(8):277-80.
The treatment of the acute renal allograft rejection with the monoclonal antibody orthoclone OKT3 produces both systemic and neurologic alterations. In a series of 21 patients with an acute renal allograft rejection treated with this monoclonal antibody, 20 with a renal allograft transplantation and one with a renal and pancreatic allograft transplantation, 29% referred headache associated with fever and vomiting, and 14.2% presented severe neurological alterations induced by the treatment. We stress the need to know these secondary effects to differentiate them from other central nervous system disorders, particularly those of infectious origin.
用单克隆抗体抗胸腺细胞球蛋白（Orthoclone OKT3）治疗急性肾移植排斥反应会产生全身和神经方面的改变。在一系列21例接受该单克隆抗体治疗的急性肾移植排斥反应患者中，20例为肾移植患者，1例为肾胰联合移植患者，29%的患者称出现与发热和呕吐相关的头痛，14.2%的患者出现由治疗引起的严重神经改变。我们强调有必要了解这些副作用，以便将它们与其他中枢神经系统疾病区分开来，尤其是那些由感染引起的疾病。
