• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗胆碱能药物。4. 含氟乙酰胆碱拮抗剂的立体控制合成；两种1-环己基-1-(4-氟苯基)-3-哌啶基-1-丙醇及其甲碘化物的合成。

Anticholinergic agents. 4. Stereocontrolled synthesis of fluorinated acetylcholine antagonists; syntheses of the two 1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanols and their methiodides.

作者信息

Sjö P, Aasen A J

机构信息

Department of Pharmacy, University of Oslo, Norway.

出版信息

Acta Chem Scand (Cph). 1993 Oct;47(10):1019-24. doi: 10.3891/acta.chem.scand.47-1019.

DOI:10.3891/acta.chem.scand.47-1019
PMID:8240907
Abstract

Four new putative muscarinic antagonists, (R)-(-)- and (S)-(+)-1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanol and their methiodides, have been synthesised. Absolute configurations have been assigned on the basis of the anticipated chirality of the products of the Sharpless asymmetric epoxidation reaction.

摘要

已合成了四种新的假定毒蕈碱拮抗剂，即(R)-(-)-和(S)-(+)-1-环己基-1-(4-氟苯基)-3-哌啶基-1-丙醇及其甲碘化物。基于Sharpless不对称环氧化反应产物预期的手性确定了绝对构型。

相似文献

1
Anticholinergic agents. 4. Stereocontrolled synthesis of fluorinated acetylcholine antagonists; syntheses of the two 1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanols and their methiodides.抗胆碱能药物。4. 含氟乙酰胆碱拮抗剂的立体控制合成；两种1-环己基-1-(4-氟苯基)-3-哌啶基-1-丙醇及其甲碘化物的合成。
Acta Chem Scand (Cph). 1993 Oct;47(10):1019-24. doi: 10.3891/acta.chem.scand.47-1019.
2
Anticholinergic agents. 2. Absolute configurations of 2-methyl-1,1-diphenyl-3-(1-piperidyl)-1-propanol and 2-methyl-1,1-diphenyl-3-(1-pyrrolidyl)-1-propanol. Crystal structures of the corresponding mandelates.抗胆碱能药物。2. 2-甲基-1,1-二苯基-3-(1-哌啶基)-1-丙醇和2-甲基-1,1-二苯基-3-(1-吡咯烷基)-1-丙醇的绝对构型。相应扁桃酸盐的晶体结构。
Acta Chem Scand (Cph). 1990 Oct;44(9):957-62. doi: 10.3891/acta.chem.scand.44-0957.
3
Syntheses of (S)-(+)-trihexyphenidyl hydrochloride and (S)-(+)-procyclidine hydrochloride, two anticholinergics, using (S)-(-)-3-cyclohexyl-3-hydroxy-3-phenylpropanoic acid as chiral synthon.
Acta Chem Scand B. 1987 May;41(5):356-61. doi: 10.3891/acta.chem.scand.41b-0356.
4
The pharmacology of 3-(N-piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloric acid (artane) and related compounds; new antispasmodic agents.3-（N-哌啶基）-1-苯基-1-环己基-1-丙醇盐酸盐（安坦）及相关化合物的药理学；新型抗痉挛剂
J Pharmacol Exp Ther. 1949 Jun;96(2):151-65.
5
Clinical experiences in parkinsonism with a new type of antispasmodic, 3-(piperidyl)-1-phenyl-1-cyclohexyl-1-propanol hydrochloride (artane).新型抗痉挛药物3-（哌啶基）-1-苯基-1-环己基-1-丙醇盐酸盐（安坦）治疗帕金森综合征的临床经验
Am J Med Sci. 1949 Dec;218(6):655-9. doi: 10.1097/00000441-194921860-00007.
6
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane 3-oxide methiodides.毒蕈碱拮抗剂的对映选择性。异构的2-环己基-2-苯基-5-[(二甲氨基)甲基]-1,3-氧硫杂环戊烷3-氧化物甲碘化物。
J Med Chem. 1989 Oct;32(10):2269-73. doi: 10.1021/jm00130a007.
7
Antagonism by (R)- and (S)-trihexyphenidyl of muscarinic stimulation of adenylyl cyclase in rat olfactory bulb and inhibition in striatum and heart.（R）-和（S）-苯海索对大鼠嗅球中毒蕈碱刺激腺苷酸环化酶以及对纹状体和心脏中该酶抑制作用的拮抗效应
Br J Pharmacol. 1994 Nov;113(3):775-80. doi: 10.1111/j.1476-5381.1994.tb17060.x.
8
Differences in the stereospecificity of closely related compounds; a reinvestigation of the enantiomers of procyclidine, benzhexol and their metho- and etho-salts.
J Pharm Pharmacol. 1971 Feb;23(2):90-7. doi: 10.1111/j.2042-7158.1971.tb08618.x.
9
Comparative behavioral and neurochemical activities of cholinergic antagonists in rats.大鼠体内胆碱能拮抗剂的比较行为学和神经化学活性
J Pharmacol Exp Ther. 1993 Oct;267(1):16-24.
10
[ASPECTS OF THE ANTICHOLINERGIC ACTION OF A NEW SPASMOLYTIC: 1-ALPHA-THIENYL-1-PHENYL-3-N-METHYLMORPHOLINE-1-PROPANOL IODIDE].[一种新型解痉药的抗胆碱能作用：1-α-噻吩基-1-苯基-3-N-甲基吗啉-1-丙醇碘化物的相关方面]
Clin Ter. 1963 Oct 15;27:39-45.

引用本文的文献

1
Synthesis of vinyl-substituted alcohols using acetylene as a C2 building block.以乙炔作为C2结构单元合成乙烯基取代的醇类。
Chem Sci. 2022 Dec 23;14(7):1912-1918. doi: 10.1039/d2sc06400f. eCollection 2023 Feb 15.