抗胆碱能药物。4. 含氟乙酰胆碱拮抗剂的立体控制合成；两种1-环己基-1-(4-氟苯基)-3-哌啶基-1-丙醇及其甲碘化物的合成。
Anticholinergic agents. 4. Stereocontrolled synthesis of fluorinated acetylcholine antagonists; syntheses of the two 1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanols and their methiodides.
作者信息
Sjö P, Aasen A J
机构信息
Department of Pharmacy, University of Oslo, Norway.
出版信息
Acta Chem Scand (Cph). 1993 Oct;47(10):1019-24. doi: 10.3891/acta.chem.scand.47-1019.
Abstract
Four new putative muscarinic antagonists, (R)-(-)- and (S)-(+)-1-cyclohexyl-1-(4-fluorophenyl)-3-piperidyl-1-propanol and their methiodides, have been synthesised. Absolute configurations have been assigned on the basis of the anticipated chirality of the products of the Sharpless asymmetric epoxidation reaction.
摘要
已合成了四种新的假定毒蕈碱拮抗剂，即(R)-(-)-和(S)-(+)-1-环己基-1-(4-氟苯基)-3-哌啶基-1-丙醇及其甲碘化物。基于Sharpless不对称环氧化反应产物预期的手性确定了绝对构型。
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