甾体激素在体外调节猪颗粒细胞中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的生成。
Steroid hormones regulate cAMP and cGMP production by porcine granulosa cells in vitro.
作者信息
Sirotkin A V, Nitray J
机构信息
Research Institute of Animal Production, Nitra, Slovakia.
出版信息
J Steroid Biochem Mol Biol. 1993 Nov;46(5):573-7. doi: 10.1016/0960-0760(93)90184-x.
The influence of steroid hormones on the output of the cyclic nucleotides adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP) by porcine granulosa cells was investigated. Both progesterone (100, 1000, 10,000 and 100,000 pg/ml medium) and estradiol (100, 1000, 10,000 and 100,000 pg/ml medium) activated cAMP and cGMP production. Testosterone (100 or 1000 pg/ml medium) also stimulated cAMP output. The stimulating effect of steroid hormones on cyclic nucleotide production may suggest the involvement of cAMP- and cGMP-dependent intracellular mechanisms in the action of steroid hormones on porcine ovarian cells.
研究了甾体激素对猪颗粒细胞中环核苷酸3',5'-环磷酸腺苷（cAMP）和3',5'-环磷酸鸟苷（cGMP）产量的影响。孕酮（培养基中浓度为100、1000、10000和100000 pg/ml）和雌二醇（培养基中浓度为100、1000、10000和100000 pg/ml）均可激活cAMP和cGMP的生成。睾酮（培养基中浓度为100或1000 pg/ml）也可刺激cAMP的产量。甾体激素对环核苷酸生成的刺激作用可能表明，cAMP和cGMP依赖性细胞内机制参与了甾体激素对猪卵巢细胞的作用。
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