Brittain E H, Bailey K R
Biostatistics Research Branch, NHLBI, Bethesda, Maryland 20892.
Biometrics. 1993 Sep;49(3):763-72.
Optimal critical values and times of intermediate testing points are determined to minimize expected sample size in a variety of situations. Two-stage and three-stage models are considered for a variety of values of power. We investigate the robustness of the optimality parameters.
确定中间测试点的最佳临界值和时间，以在各种情况下最小化预期样本量。针对各种功效值考虑了两阶段和三阶段模型。我们研究了最优性参数的稳健性。
