Baum T, Peters J R, Butz F, Much D R
Eur J Pharmacol. 1976 Oct;39(2):323-9. doi: 10.1016/0014-2999(76)90142-4.
Ventricular dysrhythmias result from changes in the automaticity or the conduction properties of the specialized conduction system. Tricyclic antidepressants have been reported to cause ventricular dysrhythmias in humans and experimental animals. Consequently, it seemed to interest to determine whether these substances influence ventricular automaticity. Ventricular rhythm was produced in anesthetized dogs by blocking atrioventricular conduction. Low doses of imipramine, amitriptyline and nortriptyline resulted in small but significant increases in automaticity. Relatively high doses of these agents suppressed automaticity markedly. These changes could play a role in the development of dysrhythmias.
室性心律失常是由特殊传导系统的自律性或传导特性改变引起的。据报道，三环类抗抑郁药可在人类和实验动物中导致室性心律失常。因此，确定这些物质是否影响心室自律性似乎很有意义。通过阻断房室传导在麻醉犬中诱发室性心律。低剂量的丙咪嗪、阿米替林和去甲替林导致自律性有小幅但显著的增加。相对高剂量的这些药物可明显抑制自律性。这些变化可能在心律失常的发生中起作用。
