De Ponti C, Ciliberto G R
G Ital Cardiol. 1976;6(4):628-33.
The effect of 10 mg of sublingual isosorbide dinitrate were studied using exercise test in 10 patients with stable angina pectoris. First the reproducibility of angina threshold of each patient was controlled. then the effects after 30, 90, 150 minutes of the administration of the drug and a placebo, administered in random sequence, were studied. No significant changes of the parameters examined were observed after the placebo. Significant increase of duration of exercise and total amount of work performed before angina were observed after the drugs. Also, the appearance of electrocardiographic alterations was retarded, and disappearance of pain after exercise interruption was quicker. These changes were maximal in the tests made 30 minutes after administration of the drug, declining therafter; nevertheless, statistically significant differences from placebo were also observed in tests after 90 and 150 minutes.
采用运动试验对10例稳定型心绞痛患者研究了10mg舌下含服硝酸异山梨酯的效果。首先控制每位患者心绞痛阈值的可重复性。然后，随机依次给予药物和安慰剂，研究给药后30、90、150分钟的效果。给予安慰剂后，所检查的参数未观察到显著变化。给予药物后，观察到运动持续时间和心绞痛发作前完成的总工作量显著增加。此外，心电图改变的出现延迟，运动中断后疼痛消失更快。这些变化在给药后30分钟的试验中最大，之后逐渐下降；然而，在90和150分钟后的试验中，与安慰剂相比也观察到统计学上的显著差异。
