癌症化疗多药耐药性的逆转。
Reversal of multidrug resistance to cancer chemotherapy.
作者信息
Leyland-Jones B, Dalton W, Fisher G A, Sikic B I
机构信息
Department of Oncology, McGill University, Montreal, Quebec, Canada.
出版信息
Cancer. 1993 Dec 1;72(11 Suppl):3484-8. doi: 10.1002/1097-0142(19931201)72:11+<3484::aid-cncr2820721615>3.0.co;2-l.
Abstract
In the past few years, the role of membrane-bound transport genes in human disease has been increasingly recognized and understood. Of these genes, the p170 membrane glycoprotein may function as an outward transport pump for many cancer chemotherapeutic drugs associated with the multidrug resistance phenotype. This article reviews the different classes of the current major modulators of multidrug resistance.
摘要
在过去几年中，膜结合转运基因在人类疾病中的作用已得到越来越多的认识和理解。在这些基因中，p170膜糖蛋白可能作为许多与多药耐药表型相关的癌症化疗药物的外向转运泵。本文综述了当前多药耐药的主要调节剂的不同类别。
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