急性白血病之前的t(8;21)
t(8;21) prior to acute leukemia.
作者信息
Berger R, Hillion J, Janvier D, Chen Z, Bussel A
机构信息
INSERM U 301, Paris, France.
出版信息
Cancer Genet Cytogenet. 1993 Oct 15;70(2):125-6. doi: 10.1016/0165-4608(93)90181-k.
A t(8;21)(q22;q22) without blood and bone marrow invasion by immature myeloid precursor cells occurred in a patient previously treated for polycythemia vera. The presence of a molecular rearrangement confirmed that the chromosomal abnormality was identical to that observed in acute leukemia with t(8;21). This case shows that the translocation, t(8;21), may occur in myelodysplasia and suggests that it can precede the appearance of overt leukemia.
一名曾接受真性红细胞增多症治疗的患者发生了t(8;21)(q22;q22)，且未出现未成熟髓系前体细胞的血液和骨髓浸润。分子重排的存在证实该染色体异常与在伴有t(8;21)的急性白血病中观察到的异常相同。该病例表明，t(8;21)易位可能发生在骨髓增生异常综合征中，并提示它可能先于明显白血病的出现。
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