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1
Interleukin-4 plus tumor necrosis factor alpha augments the antigenicity of melanoma cells.白细胞介素-4加肿瘤坏死因子α增强黑色素瘤细胞的抗原性。
Cancer Immunol Immunother. 1993 Nov;37(6):378-84. doi: 10.1007/BF01526794.
2
Generation of melanoma-specific, cytotoxic CD4(+) T helper 2 cells: requirement of both HLA-DR15 and Fas antigens on melanomas for their lysis by Th2 cells.黑色素瘤特异性细胞毒性CD4(+)辅助性T细胞2的产生：黑色素瘤上的HLA - DR15和Fas抗原对其被Th2细胞裂解均有需求。
Cell Immunol. 2001 Jun 15;210(2):96-105. doi: 10.1006/cimm.2001.1809.
3
Effects of interferon-gamma and tumour necrosis factor-alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma.γ-干扰素和肿瘤坏死因子-α对人黑色素瘤自体混合淋巴细胞肿瘤培养中细胞毒性T淋巴细胞发育的影响。
Clin Exp Immunol. 1991 Oct;86(1):163-72. doi: 10.1111/j.1365-2249.1991.tb05790.x.
4
Modulation of human melanoma cells by interleukin-4 and in combination with gamma-interferon or alpha-tumor necrosis factor.白细胞介素-4以及与γ-干扰素或α-肿瘤坏死因子联合使用对人黑素瘤细胞的调节作用
Cancer Res. 1991 Apr 15;51(8):2002-8.
5
Differential modulation by tumor necrosis factor and immune interferon of HLA class-II antigens expressed by melanoma cells.肿瘤坏死因子和免疫干扰素对黑色素瘤细胞表达的HLA-II类抗原的差异调节
Int J Cancer. 1989 Sep 15;44(3):554-9. doi: 10.1002/ijc.2910440330.
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Interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) are necessary in the early stages of induction of CD4 and CD8 cytotoxic T cells by Mycobacterium leprae heat shock protein (hsp) 65 kD.γ干扰素（IFN-γ）和肿瘤坏死因子-α（TNF-α）在麻风分枝杆菌65kD热休克蛋白（hsp）诱导CD4和CD8细胞毒性T细胞的早期阶段是必需的。
Clin Exp Immunol. 1998 Nov;114(2):196-203. doi: 10.1046/j.1365-2249.1998.00702.x.
7
Increasing infiltration and activation of CD8+ tumor-infiltrating lymphocytes after eliminating immune suppressive granulocyte/macrophage progenitor cells with low doses of interferon gamma plus tumor necrosis factor alpha.在使用低剂量干扰素γ加肿瘤坏死因子α消除免疫抑制性粒细胞/巨噬细胞祖细胞后，CD8 +肿瘤浸润淋巴细胞的浸润和活化增加。
Cancer Immunol Immunother. 1994 Jan;38(1):9-15. doi: 10.1007/BF01517164.
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Clonal analysis of in vivo activated CD8+ cytotoxic T lymphocytes from a melanoma patient responsive to active specific immunotherapy.对一名对主动特异性免疫疗法有反应的黑色素瘤患者体内活化的CD8 + 细胞毒性T淋巴细胞进行克隆分析。
Cancer Immunol Immunother. 1993 Jul;37(1):15-25. doi: 10.1007/BF01516937.
9
T lymphocytes can mediate lysis of autologous melanoma cells by multiple mechanisms: evidence with a single T cell clone.T淋巴细胞可通过多种机制介导对自体黑色素瘤细胞的裂解：来自单个T细胞克隆的证据。
Cancer Immunol Immunother. 1990;32(1):13-21. doi: 10.1007/BF01741719.
10
Interleukin 10 pretreatment protects target cells from tumor- and allo-specific cytotoxic T cells and downregulates HLA class I expression.白细胞介素10预处理可保护靶细胞免受肿瘤特异性和同种异体特异性细胞毒性T细胞的攻击，并下调HLA I类分子的表达。
J Exp Med. 1994 Dec 1;180(6):2371-6. doi: 10.1084/jem.180.6.2371.

引用本文的文献

1
Intermittent interferon and polychemotherapy in metastatic melanoma.转移性黑色素瘤的间歇性干扰素与多药化疗
J Cancer Res Clin Oncol. 1995;121(3):175-80. doi: 10.1007/BF01198100.

本文引用的文献

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MHC imbalance and metastatic spread in Lewis lung carcinoma clones.Lewis肺癌克隆中的MHC失衡与转移扩散
Int J Cancer. 1983 Jul 15;32(1):113-20. doi: 10.1002/ijc.2910320118.
2
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains.一个人类T细胞特异性cDNA克隆编码一种与免疫球蛋白链具有广泛同源性的蛋白质。
Nature. 1984;308(5955):145-9. doi: 10.1038/308145a0.
3
OKT4+ cytotoxic T cells can lyse targets via class I molecules and can be blocked by monoclonal antibody against T4 molecules.OKT4 + 细胞毒性T细胞可通过I类分子裂解靶细胞，并且可被抗T4分子的单克隆抗体阻断。
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Surface antigens of melanoma and melanocytes. Specificity of induction of Ia antigens by human gamma-interferon.黑色素瘤和黑素细胞的表面抗原。人γ干扰素诱导Ia抗原的特异性。
J Exp Med. 1984 Jul 1;160(1):255-69. doi: 10.1084/jem.160.1.255.
5
Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene.通过主要组织相容性复合体I类基因的表达逆转肿瘤发生。
Science. 1985 Apr 5;228(4695):26-30. doi: 10.1126/science.3975631.
6
B-cell stimulatory factor-1/interleukin 4.B细胞刺激因子-1/白细胞介素4
Annu Rev Immunol. 1987;5:429-59. doi: 10.1146/annurev.iy.05.040187.002241.
7
Modulation of phenotypic and functional properties of human peripheral blood monocytes by IL-4.白细胞介素-4对人外周血单核细胞表型和功能特性的调节作用
J Immunol. 1988 Mar 1;140(5):1548-54.
8
Autologous tumor-specific cytotoxic T lymphocytes in the infiltrate of human metastatic melanomas. Activation by interleukin 2 and autologous tumor cells, and involvement of the T cell receptor.人类转移性黑色素瘤浸润中的自体肿瘤特异性细胞毒性T淋巴细胞。白细胞介素2和自体肿瘤细胞的激活作用以及T细胞受体的参与。
J Exp Med. 1988 Oct 1;168(4):1419-41. doi: 10.1084/jem.168.4.1419.
9
In vitro antigenic modulation of human neuroblastoma cells induced by IFN-gamma, retinoic acid and dibutyryl cyclic AMP.γ干扰素、视黄酸和二丁酰环磷腺苷对人神经母细胞瘤细胞的体外抗原调节作用
Int J Cancer. 1987 Apr 15;39(4):521-9. doi: 10.1002/ijc.2910390420.
10
Recombinant gamma-interferon induces changes in expression and shedding of antigens associated with normal human melanocytes, nevus cells, and primary and metastatic melanoma cells.重组γ干扰素可诱导与正常人黑素细胞、痣细胞以及原发性和转移性黑色素瘤细胞相关的抗原表达及脱落发生变化。
J Immunol. 1985 Jun;134(6):4226-30.

白细胞介素-4加肿瘤坏死因子α增强黑色素瘤细胞的抗原性。

Interleukin-4 plus tumor necrosis factor alpha augments the antigenicity of melanoma cells.

作者信息

Hoon D S, Hayashi Y, Morisaki T, Foshag L J, Morton D L

机构信息

John Wayne Cancer Institute, Saint John's Hospital and Health Center, Santa Monica, CA 90404.

出版信息

Cancer Immunol Immunother. 1993 Nov;37(6):378-84. doi: 10.1007/BF01526794.

DOI:10.1007/BF01526794
PMID:8242663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11038140/
Abstract

Immune cytokines are important regulators of the immune response to neoplastic cells. We previously reported that interleukin 4 (IL-4) and either tumor necrosis factor alpha (TNF) or interferon gamma (IFN) synergistically inhibit melanoma cell growth and induce cell differentiation. In the present study we used various combinations of IL-4, IFN and TNF to enhance the antigenicity of melanoma cells. IL-4 plus TNF significantly increased the ability of melanoma cells to stimulate cytotoxic T cells (CTL) and act as targets of these CTL; IL-4 plus IFN was somewhat less effective, while TNF plus IFN was not as effective. IL-4 plus TNF also increased the expression of HLA class I and HLA-DR antigens on melanoma cells. The CTL lines examined in this study were CD3+CD4+ and oligoclonal. These preclinical results suggest that the immune response to melanoma whole-cell vaccines might be enhanced by pretreating vaccine cells with IL-4 plus TNF.

摘要

免疫细胞因子是对肿瘤细胞免疫反应的重要调节因子。我们之前报道过白细胞介素4（IL-4）与肿瘤坏死因子α（TNF）或干扰素γ（IFN）协同抑制黑色素瘤细胞生长并诱导细胞分化。在本研究中，我们使用IL-4、IFN和TNF的各种组合来增强黑色素瘤细胞的抗原性。IL-4加TNF显著提高了黑色素瘤细胞刺激细胞毒性T细胞（CTL）的能力，并使其成为这些CTL的靶标；IL-4加IFN的效果稍差，而TNF加IFN则效果不佳。IL-4加TNF还增加了黑色素瘤细胞上HLA I类和HLA-DR抗原的表达。本研究中检测的CTL系为CD3 + CD4 +且是寡克隆的。这些临床前结果表明，用IL-4加TNF预处理疫苗细胞可能会增强对黑色素瘤全细胞疫苗的免疫反应。