[与卵巢癌相关的两种抗原OC41 D和OC41 E的特性分析]

[Characterization of two antigens OC41 D and OC41 E associated with ovarian carcinoma].

作者信息

Cui H

机构信息

People's Hospital, Beijing Medical University.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 1993 May;28(5):284-6, 314-5.

PMID:8243148

Abstract

Two antigens, OC41D and OC41E, were characterized by two monoclonal antibodies (COC41D and COC41E) generated with the antigens (OC41) as immunogen, which were dissociated from immune complex in a patient with ovarian carcinoma. The expressing rates of the antigen OC41D and OC41E were 70.2% and 52.5% in epithelial ovarian cancer. They were mainly detected on the membrane of the cancer cells, also a little in the plasma. Two antigens were found no cross reactivities with HIA, CEA, alpha-FP, and beta-MG. Their express were not related to cell circle. Antigen OC41D might be a protein with molecular weight of 62,000 and could not be denatured by heating. Antigen OC41E might be a glycoprotein with molecular weight of 15,000. These two antigens may be new antigens highly associated with ovarian carcinoma.

摘要

两种抗原，OC41D和OC41E，由以抗原（OC41）为免疫原产生的两种单克隆抗体（COC41D和COC41E）进行表征，这两种抗原是从一名卵巢癌患者的免疫复合物中解离出来的。抗原OC41D和OC41E在上皮性卵巢癌中的表达率分别为70.2%和52.5%。它们主要在癌细胞膜上检测到，在血浆中也有少量存在。发现这两种抗原与HIA、CEA、α-FP和β-MG无交叉反应。它们的表达与细胞周期无关。抗原OC41D可能是一种分子量为62,000的蛋白质，加热后不会变性。抗原OC41E可能是一种分子量为15,000的糖蛋白。这两种抗原可能是与卵巢癌高度相关的新抗原。