Wolf R, Strehle F, Emrich H M
Max-Planck-Institute for Psychiatry, Clinical Institute, Munich, Germany.
Epilepsia. 1993 Nov-Dec;34(6):1110-6. doi: 10.1111/j.1528-1157.1993.tb02142.x.
In vivo effects of carbamazepine (CBZ) on the neuroendocrine preopticopituitary feedback system were studied by local application of CBZ through a push-pull cannula into the preoptic area and measurement of local effects on gamma-aminobutyric acid (GABA) and distant effects on a subsequent biologic response: luteinizing hormone (LH). Perfusion with 8 and 12 micrograms CBZ/ml cerebrospinal fluid caused a reduction in preoptic GABA release and concomitant suppression of plasma LH levels. These results suggest a GABA component to the mechanism(s) of action of CBZ: (a) CBZ reduces extracellular available GABA concentration, and (b) owing to the known inhibitory role of preoptic GABA in pituitary LH secretion, an increase of postsynaptic GABAergic transmission by CBZ itself could be inferred.
通过推挽式套管将卡马西平（CBZ）局部应用于视前区，并测量其对γ-氨基丁酸（GABA）的局部作用以及对随后生物反应——黄体生成素（LH）的远距离作用，研究了卡马西平（CBZ）在体内对神经内分泌视前-垂体反馈系统的影响。用8微克/毫升和12微克/毫升的CBZ灌注脑脊液会导致视前区GABA释放减少，并伴随血浆LH水平的抑制。这些结果表明GABA是CBZ作用机制的一个组成部分：（a）CBZ降低细胞外可用GABA浓度，（b）由于已知视前区GABA对垂体LH分泌具有抑制作用，因此可以推断CBZ本身会增加突触后GABA能传递。
