Root A W, Diamond F B
Department of Pediatrics, University of South Florida College of Medicine, Tampa.
Endocrinol Metab Clin North Am. 1993 Sep;22(3):573-92.
During adolescence, there are marked changes in the metabolism of calcium and phosphorus and a dramatic increase in the rate of bone mineralization under the influence of the sex hormones, growth hormone, and insulin-like growth factor-1. More than 50% of adult bone mass is accumulated during puberty; failure to achieve maximum bone mineralization at this time may lead to osteopenia and its complications in later adulthood. This article discusses the causes, evaluation, and management of adolescents with hypocalcemia, hypercalcemia, and disorders of bone mineralization.
在青春期，钙和磷的代谢会发生显著变化，在性激素、生长激素和胰岛素样生长因子-1的影响下，骨矿化速率急剧增加。超过50%的成人骨量在青春期积累；此时未能实现最大骨矿化可能会导致成年后期出现骨质减少及其并发症。本文讨论青少年低钙血症、高钙血症和骨矿化障碍的病因、评估及管理。
