McDonald A, MacDonald E, Wadsworth R M, Scott P J
Department of Physiology and Pharmacology, University of Strathclyde, Glasgow, Scotland, UK.
Eur J Pharmacol. 1993 Aug 24;240(2-3):303-5. doi: 10.1016/0014-2999(93)90914-4.
Human mesenteric artery rings (1-3 mm diameter obtained from bowel resections), precontracted with KCl 80 mM, were relaxed by cromakalim (IC50 = 0.39 +/- 0.04 microM, maximum inhibition 69 +/- 2%). Cromakalim was more effective at inhibiting KCl 40 mM than KCl 80 mM. Cromakalim also inhibited contraction produced by noradrenaline, and was a more potent inhibitor of the second phase of the noradrenaline contraction than of the first phase.
人肠系膜动脉环（取自肠切除标本，直径1 - 3毫米），用80毫摩尔氯化钾预收缩后，可被克罗卡林舒张（半数抑制浓度=0.39±0.04微摩尔，最大抑制率69±2%）。克罗卡林对40毫摩尔氯化钾收缩的抑制作用比对80毫摩尔氯化钾收缩的抑制作用更有效。克罗卡林还可抑制去甲肾上腺素引起的收缩，且对去甲肾上腺素收缩第二相的抑制作用比对第一相的抑制作用更强。
