反复接触可卡因会导致血清素对催乳素和肾素的刺激产生长期缺陷，但不会影响促肾上腺皮质激素的分泌。
Repeated exposure to cocaine produces long-lasting deficits in the serotonergic stimulation of prolactin and renin, but not adrenocorticotropin secretion.
作者信息
Levy A D, Rittenhouse P A, Bonadonna A M, Alvarez Sanz M C, Bethea C L, Van de Kar L D
机构信息
Department of Pharmacology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153.
出版信息
Eur J Pharmacol. 1993 Sep 14;241(2-3):275-8. doi: 10.1016/0014-2999(93)90215-4.
To determine whether cocaine-induced deficits in serotonergic function are long-lasting, the neuroendocrine responses to the serotonin (5-hydroxytryptamine, 5-HT) releaser, p-chloroamphetamine were evaluated 1-8 weeks subsequent to 7 days of cocaine exposure (15 mg/kg b.i.d.). In cocaine-pretreated rats, the p-chloroamphetamine-induced elevations of prolactin and renin secretion were significantly reduced for 8 and 4 weeks, respectively. In contrast, the p-chloroamphetamine-induced elevation of adrenocorticotropic hormone (ACTH) secretion was at control values 1 week after cocaine exposure. The data suggest that some cocaine-induced deficits in serotonergic function are long-lasting.
为了确定可卡因引起的血清素能功能缺陷是否持久，在暴露于可卡因（15毫克/千克，每日两次）7天后的1至8周，评估了对血清素（5-羟色胺，5-HT）释放剂对氯苯丙胺的神经内分泌反应。在经可卡因预处理的大鼠中，对氯苯丙胺引起的催乳素和肾素分泌升高分别在8周和4周时显著降低。相比之下，对氯苯丙胺引起的促肾上腺皮质激素（ACTH）分泌升高在可卡因暴露后1周时处于对照值。数据表明，一些可卡因引起的血清素能功能缺陷是持久的。
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