DePriest P D, Shenson D, Fried A, Hunter J E, Andrews S J, Gallion H H, Pavlik E J, Kryscio R J, van Nagell J R
Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington 40536.
Gynecol Oncol. 1993 Oct;51(1):7-11. doi: 10.1006/gyno.1993.1238.
A morphology index based on morphologic characteristics of ovarian tumors was developed. Specific categories included tumor volume, wall structure, and septal structure. A point scale (0-4) was developed within each category with the total points per evaluation varying from 0-12. Sonograms on 121 patients undergoing exploratory laparotomy for ovarian masses were evaluated using this index. Eighty ovarian tumors had a morphology index score < 5, and all were benign (negative predictive value, 1.000). In postmenopausal patients, a morphology index score > or = 5 had a positive predictive value for malignancy of 0.45. All ovarian malignancies had significant abnormalities in wall structure and all had a total volume in excess of 10 cm3. The findings of the present investigation indicate that the morphology index is a cost effective adjuvant method which significantly increases the specificity and positive predictive value of transvaginal sonography. The routine application of a morphology index to screening sonography should decrease the amount of diagnostic surgery performed in order to detect each case of ovarian cancer.
基于卵巢肿瘤形态学特征开发了一种形态学指数。具体类别包括肿瘤体积、壁结构和间隔结构。在每个类别中制定了一个评分标准（0 - 4分），每次评估的总分在0 - 12分之间变化。使用该指数对121例因卵巢肿块接受剖腹探查术的患者的超声图像进行了评估。80例卵巢肿瘤的形态学指数评分<5分，且均为良性（阴性预测值为1.000）。在绝经后患者中，形态学指数评分>或 = 5分对恶性肿瘤的阳性预测值为0.45。所有卵巢恶性肿瘤的壁结构均有明显异常，且总体积均超过10 cm³。本研究结果表明，形态学指数是一种经济有效的辅助方法，可显著提高经阴道超声检查的特异性和阳性预测值。将形态学指数常规应用于超声筛查应可减少为检测每例卵巢癌而进行的诊断性手术数量。
