Takamatsu S, Rho M, Hayashi M, Komiyama K, Tanaka H, Omura S, Imokawa G
Kitasato Institute, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 1993 Oct;46(10):1526-9. doi: 10.7164/antibiotics.46.1526.
New melanin synthesis inhibitors, OH-3984 K1 and K2, were isolated from the fermentation broth of Streptomyces sp. OH-3984, and their structures were elucidated by spectroscopic methods and by chemical transformations. OH-3984 K1 (M.W.: 306; C18H26O4) and K2 (M.W.: 308; C18H28O4) have unique gamma-lactone rings, both of which correspond to oxidative products derived from C1-O14 cleavage of the 14-membered lactone group.
