Lee D Y, Chung C Y, Choi I H
Seoul National University Children's Hospital, South Korea.
J Bone Joint Surg Br. 1993 Nov;75(6):898-903. doi: 10.1302/0301-620X.75B6.8245079.
We investigated the effect of bone lengthening by callotasis on longitudinal growth of the tibia in rabbits. Ninety-nine five-week-old immature rabbits were divided into five groups according to the percentage of lengthening: group I, 10%; group II, 20%; group III, 30%; group IV, 40%; and group V, sham operation without lengthening. Corticotomy was performed at the proximal metaphysis of the left tibia and the right tibia was used as a control. The lengthening rate was 0.25 mm twice daily. Radiological, histomorphometric, and immunohistochemical studies were done on animals killed at the time of corticotomy, at the completion of lengthening, and thereafter every two weeks until 12 weeks. Tibial lengthening did not cause retardation of growth when the bone was lengthened by up to 20%. When the bone was lengthened by 30% or more, growth retardation was evident, and persisted until skeletal maturity.
我们研究了骨痂延长术对兔胫骨纵向生长的影响。将99只5周龄的未成熟兔根据延长百分比分为五组：第一组，10%；第二组，20%；第三组，30%；第四组，40%；第五组，未延长的假手术组。在左胫骨近端干骺端进行皮质切开术，右侧胫骨作为对照。延长速率为每日两次，每次0.25毫米。在皮质切开术时、延长完成时以及此后每两周直至12周对处死的动物进行放射学、组织形态计量学和免疫组织化学研究。当骨延长达20%时，胫骨延长未导致生长迟缓。当骨延长30%或更多时，生长迟缓明显，并持续至骨骼成熟。
