口腔黏膜癌前病变和肿瘤性病变中p53与Ki 67的表达
p53 and Ki 67 expression in preneoplastic and neoplastic lesions of the oral mucosa.
作者信息
Girod S C, Krueger G, Pape H D
机构信息
Department of Oral and Maxillofacial Surgery, University of Cologne, Germany.
出版信息
Int J Oral Maxillofac Surg. 1993 Oct;22(5):285-8. doi: 10.1016/s0901-5027(05)80517-x.
Some lesions of the oral mucosa such as leukoplakia and erythroplakia may develop into squamous cell carcinoma (SCC). At present, however, there is no method available to predict malignant transformation. It is known that the grade of dysplasia is related to the potential malignant development, but this is unreliable as the only indicator. In 64 hyperplastic lesions and 85 SCC of the oral mucosa, a correlation between the expression of the mutated tumor-suppressor gene p53 and the dysplasia of the lesions was found. Ki 67 was used as a proliferation marker. The results imply that expression of mutated p53 is an indicator for potential malignant development in benign lesions of the oral mucosa.
一些口腔黏膜病变，如白斑和红斑，可能会发展为鳞状细胞癌（SCC）。然而，目前尚无可用方法预测恶性转化。已知发育异常的程度与潜在的恶性发展相关，但作为唯一指标并不可靠。在64例口腔黏膜增生性病变和85例SCC中，发现突变的肿瘤抑制基因p53的表达与病变的发育异常之间存在相关性。Ki 67用作增殖标志物。结果表明，突变型p53的表达是口腔黏膜良性病变潜在恶性发展的一个指标。
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