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[不同类型心功能不全中血管扩张剂的差异应用]

[Differential use of vasodilators in various types of cardiac insufficiency].

作者信息

Moiseev V S, Shatkovskiĭ N P, Cheltsov V V

出版信息

Klin Med (Mosk). 1993;71(4):21-5.

PMID:8246409
Abstract

Vasodilators (captopril or nifedipine) were administered to 85 patients with stage IIA-IIB circulatory insufficiency. Of them 36 had dilated cardiomyopathy (DC), 30 ischemic heart disease (IHD), 19 suffered from essential hypertension (EH). Morphofunctionally, myocardial lesion was of a dilated type in 50 patients (36 DC, 10 IHD and 4 EH cases), of a hypertrophic type in 18 patients (4 IHD, 14 EH cases), of a mixed type in 17 IHD patients. The response to acute tests with 25 mg captopril and 20 mg nifedipine along with clinicohemodynamic results of 3-5-week course treatment with the drugs point to noticeable advantage of captopril in the dilated lesion (18 responders of 26 patients), while nifedipine in the hypertrophic type (10 responders of 10 patients). In mixed-type IHD patients both drugs displayed high efficacy.

摘要

对85例IIA-IIB期循环功能不全患者使用血管扩张剂(卡托普利或硝苯地平)。其中36例患有扩张型心肌病(DC),30例患有缺血性心脏病(IHD),19例患有原发性高血压(EH)。从形态功能上看,50例患者(36例DC、10例IHD和4例EH)的心肌病变为扩张型,18例患者(4例IHD、14例EH)为肥厚型,17例IHD患者为混合型。25毫克卡托普利和20毫克硝苯地平急性试验的反应以及药物3至5周疗程治疗的临床血液动力学结果表明,卡托普利在扩张型病变中具有显著优势(26例患者中有18例有反应),而硝苯地平在肥厚型病变中具有优势(10例患者中有10例有反应)。在混合型IHD患者中,两种药物均显示出高效。

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