Lundström K I, Karlsson J O, Svensson S P, Mårtensson L G, Elwing H, Odman S, Andersson R G
Laboratory of Applied Physics, Linköping University, Sweden.
J Theor Biol. 1993 Sep 21;164(2):135-48. doi: 10.1006/jtbi.1993.1144.
It is suggested that the physiological response caused by an excited membrane-bound receptor can be either local, i.e. localized close to the receptor site, or non-local, spreading over a large volume in the cell. A simple model is presented which shows how locality and non-locality are related to the intrinsic "efficacy" of the drug used in classical receptor theory. It is further demonstrated how the shape of the physiological response versus receptor occupancy is determined by the number of receptor sites which contribute to the physiological response at a given location in the cell.
有人提出，由兴奋的膜结合受体引起的生理反应可以是局部的，即局限于靠近受体部位，也可以是非局部的，在细胞内大面积扩散。本文提出了一个简单模型，该模型展示了局部性和非局部性如何与经典受体理论中所用药物的内在“效能”相关。进一步证明了生理反应与受体占有率的关系曲线形状是如何由在细胞给定位置对生理反应有贡献的受体位点数量决定的。
