Hisatomi K, Kosuga K, Isomura T, Hirano A, Sato S, Aoyagi S, Oishi K
Second Department of Surgery, Kurume University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1993 Sep;94(9):1047-50.
The effect of additional albumin in crystalloid cardioplegic solution (CS) was investigated for infant with open heart surgery. Patients were divided into two groups; CS containing with or without 1% albumin. CS without albumin was administered for Group-I in 13 patients and CS with albumin for Group-II in 14 patients. The blood samples were collected from radial artery and coronary sinus at 5, 15 and 30 minutes after reperfusion and blood gas analysis, hemoglobin, lactate, creatine kinase-MB (CK-MB) and malondialdehyde (MDA) were measured. In percentage of CK-MB secretion, no significant differences were seen between two groups. However, in oxygen consumption, lactate and MDA secretion, significant differences between the groups were noted at five minutes after reperfusion. In conclusion, additional albumin in CS solution, especially in infant cases was effective for myocardial preservation immediately after reperfusion.
研究了晶体心脏停搏液（CS）中添加白蛋白对接受心脏直视手术婴儿的影响。患者分为两组；分别使用含或不含1%白蛋白的CS。13例I组患者使用不含白蛋白的CS，14例II组患者使用含白蛋白的CS。在再灌注后5、15和30分钟从桡动脉和冠状窦采集血样，测量血气分析、血红蛋白、乳酸、肌酸激酶-MB（CK-MB）和丙二醛（MDA）。在CK-MB分泌百分比方面，两组之间未观察到显著差异。然而，在氧消耗、乳酸和MDA分泌方面，再灌注后5分钟两组之间存在显著差异。总之，CS溶液中添加白蛋白，特别是在婴儿病例中，对再灌注后立即的心肌保护有效。
