Traub R J, Herdegen T, Gebhart G F
Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242.
Neurosci Lett. 1993 Oct 1;160(2):121-5. doi: 10.1016/0304-3940(93)90394-z.
Thoracolumbar and lumbosacral spinal segments that receive afferent input from the descending colon and rectum were stained immunocytochemically for c-Fos- and c-Jun-like proteins following repetitive, noxious colorectal distention (CRD). Noxious CRD (80 mmHg) resulted in significantly more c-Fos- and c-Jun-like immunoreactivity in the sacral dorsal horn than in the thoracic dorsal horn. In both regions of the spinal cord the increase in c-Fos-like immunoreactivity was at least twice that of c-Jun-like immunoreactivity. Basal levels of c-Jun but not c-Fos were observed in the thoracic intermediolateral nucleus (IML) and the sacral parasympathetic nucleus (SPN). Noxious CRD induced both c-Fos and c-Jun in the SPN, but not the IML.
在重复进行有害性结直肠扩张（CRD）后，对接受来自降结肠和直肠传入输入的胸腰段和腰骶段脊髓节段进行免疫细胞化学染色，以检测c-Fos和c-Jun样蛋白。有害性CRD（80 mmHg）导致骶髓背角的c-Fos和c-Jun样免疫反应性显著高于胸髓背角。在脊髓的两个区域，c-Fos样免疫反应性的增加至少是c-Jun样免疫反应性增加的两倍。在胸髓中间外侧核（IML）和骶副交感核（SPN）中观察到c-Jun的基础水平，但未观察到c-Fos的基础水平。有害性CRD在SPN中诱导了c-Fos和c-Jun，但在IML中未诱导。
