Holcomb C, Erdmann W, Corssen G
South Med J. 1976 Oct;69(10):1282-4.
The phenomenon of "diffusion hypoxemia" seems to be a well-defined entity. To determine the degree of deoxygenation of the arterial blood due to diffusion hypoxemia, experiments were performed in monkeys which were anesthetized with ketamine, intubated, and allowed to breathe spontaneously. Blood PaO2 values were continuously monitored with the aid of an intra-arterially placed IBC PO2 electrode capable of instantly recording changes in oxygen tension. After stabilization of the blood PaO2 values with the animal breathing different mixtures of oxygen and nitrous oxide, the inspired mixture was abruptly changed to normal air. The blood PaO2 values did not show any significant fall in PaO2 with any mixture containing more than 21% oxygen. It is suggested that diffusion hypoxemia of any degree can be seen only if a patient is breathing a gas mixture containing no more than 21% oxygen.
“弥散性低氧血症”现象似乎是一个明确的实体。为了确定因弥散性低氧血症导致的动脉血脱氧程度，对用氯胺酮麻醉、插管并允许自主呼吸的猴子进行了实验。借助置于动脉内的能够即时记录氧分压变化的IBC PO₂电极持续监测血PaO₂值。在动物呼吸不同氧和氧化亚氮混合气体使血PaO₂值稳定后，将吸入气体突然改为正常空气。对于任何含氧量超过21%的混合气体，血PaO₂值均未显示出PaO₂有任何显著下降。有人提出，只有当患者呼吸含氧量不超过21%的气体混合物时，才会出现任何程度的弥散性低氧血症。
