Tanaka H, Hosaka H, Takahashi R, Imamura Y, Takai K, Yokoyama S, Takaku H
Department of Industrial Chemistry, Chiba Institute of Technology, Japan.
Nucleic Acids Symp Ser. 1993(29):175-6.
Subsequent of the discovery that RNA can have site specific cleavage activity, there has been a great deal of interest in the design and testing of trans-acting catalytic RNAs as therapeutic agents. We have chemically synthesized and experimentally analyzed chimeric DNA-RNA ribozymes in which the catalytic center remains as RNA.
在发现RNA可具有位点特异性切割活性之后，人们对设计和测试作为治疗剂的反式作用催化RNA产生了浓厚兴趣。我们已经化学合成并实验分析了嵌合DNA-RNA核酶，其中催化中心仍为RNA。
