具有交替的（3'→3'）和（5'→5'）核苷酸间连接的交替α，β-寡脱氧核糖核苷酸作为潜在治疗剂的合成。
The synthesis of alternating alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotic linkages as potential therapeutic agents.
作者信息
Koga M, Geyer S J, Regan J B, Beaucage S L
机构信息
Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.
出版信息
Nucleic Acids Symp Ser. 1993(29):3-4.
PMID:8247779
Abstract
A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated.
摘要
已经开发出一种简化的α-2'-脱氧核糖核苷衍生物合成方法，并完成了针对HIV-1 tat mRNA的具有交替（3'→3'）和（5'→5'）核苷间磷酸二酯键的反义α，β-寡脱氧核糖核苷酸的固相制备。已经研究了这些寡核苷酸类似物的杂交特性。
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