Seow W K, Thong Y H
Department of Dentistry, University of Queensland, Brisbane, Australia.
Pediatr Dent. 1993 Jul-Aug;15(4):260-6.
Tetrandrine, a bisbenzylisoquinoline alkaloid with unique broad-spectrum anti-inflammatory properties, was evaluated as a pulpotomy medicament in a canine model. Histological sections were evaluated after three days (acute inflammation) and six weeks (chronic inflammation) by two criteria: 1) intensity and degree of inflammation, and 2) extent of pulp involvement. The results of the three-day dressings revealed significant neutrophil infiltration in only 30% of teeth treated with tetrandrine, compared with 81%, 84%, and 100% of teeth treated with Ledermix, (Lederle Pharmaceuticals, Wolfrathausen, Germany), formocresol (Creighton Pharmaceuticals, Sydney, Australia) and saline (controls) respectively (P < 0.01). After six weeks, there was significant lymphocyte infiltration in only 30% of teeth treated with tetrandrine, compared with 66%, 90%, and 100% on teeth treated with Ledermix, formocresol, and saline controls respectively. (P < 0.01). In both three-day and six-week specimens in tetrandrine-treated teeth the extent of inflammation was limited to less than one-third of the coronal section of the pulp, whereas teeth treated with Ledermix or formocresol showed cellular infiltration extending to greater than two-thirds of the pulp (P < 0.01). Comparative studies with berbamine, a natural analog of tetrandrine, showed that it was less potent than tetrandrine, but significantly better than Ledermix and formocresol on both acute and chronic pulp inflammation (P < 0.05 and P < 0.01 respectively). These results suggest that tetrandrine may have value as a pulpotomy medicament.
粉防己碱是一种具有独特广谱抗炎特性的双苄基异喹啉生物碱，在犬类模型中被评估为一种牙髓切断术药物。在三天（急性炎症）和六周（慢性炎症）后，通过两个标准对组织学切片进行评估：1）炎症的强度和程度，以及2）牙髓受累程度。三天换药的结果显示，仅30%用粉防己碱治疗的牙齿中有显著的中性粒细胞浸润，相比之下，分别用利德美（德国沃尔夫拉豪森的礼来制药公司）、甲醛甲酚（澳大利亚悉尼的克赖顿制药公司）和生理盐水（对照组）治疗的牙齿中这一比例分别为81%、84%和100%（P<0.01）。六周后，仅30%用粉防己碱治疗的牙齿中有显著的淋巴细胞浸润，相比之下，分别用利德美、甲醛甲酚和生理盐水对照组治疗的牙齿中这一比例分别为66%、90%和100%（P<0.01）。在粉防己碱治疗的牙齿的三天和六周标本中，炎症程度均局限于牙髓冠部截面的不到三分之一，而用利德美或甲醛甲酚治疗的牙齿显示细胞浸润延伸至超过牙髓的三分之二（P<0.01）。与粉防己碱的天然类似物小檗胺的对比研究表明，它的效力低于粉防己碱，但在急性和慢性牙髓炎症方面均显著优于利德美和甲醛甲酚（分别为P<0.05和P<0.01）。这些结果表明粉防己碱可能作为一种牙髓切断术药物具有价值。
