Chitwood K K, Heim-Duthoy K L
Drug Evaluation Unit, Hennepin County Medical Center Pharmacy, University of Minnesota, Minneapolis, MN 55404.
Pharmacotherapy. 1993 Sep-Oct;13(5):447-54.
Calcium channel blockers are extensively used for their beneficial effects on the cardiovascular system. Solid organ transplant recipients commonly have cardiovascular disease and are often treated with these agents. Research demonstrates that calcium antagonists may have beneficial effects in this population that are independent of their effects on the cardiovascular system. Indeed, both in vitro and in vivo studies suggested that they may possess immunosuppressive properties. Their actions at the cellular level in both the afferent and efferent arms of the immune system indicate that alone, as well as in combination with cyclosporine, these agents possess immunosuppressive properties that may potentially benefit the transplant population.
钙通道阻滞剂因其对心血管系统的有益作用而被广泛使用。实体器官移植受者通常患有心血管疾病，常使用这些药物进行治疗。研究表明，钙拮抗剂在该人群中可能具有独立于其对心血管系统作用的有益效果。事实上，体外和体内研究均表明它们可能具有免疫抑制特性。它们在免疫系统传入和传出臂的细胞水平上的作用表明，这些药物单独使用以及与环孢素联合使用时，均具有免疫抑制特性，可能对移植人群有益。
