• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

成年脊椎动物的眼睛中会发生黑色素周转吗?

Does melanin turnover occur in the eyes of adult vertebrates?

作者信息

Schraermeyer U

机构信息

Institut für Biologie II (Zoologie), RWTH, Aachen, Germany.

出版信息

Pigment Cell Res. 1993 Aug;6(4 Pt 1):193-204. doi: 10.1111/j.1600-0749.1993.tb00602.x.

DOI:10.1111/j.1600-0749.1993.tb00602.x
PMID:8248016
Abstract

This paper is a review of what is known about the turnover of melanin in iris, choroid, and retinal pigment epithelium (RPE) of the adult vertebrate eye. Differences in size and structure of choroideal and retinal pigment epithelial melanin granules are shown by electron micrographs. The classical stages of melanin synthesis, including the premelanosome, are shown in the RPE of adult hamsters that had been exposed to intense light. Degradation or synthesis of melanin also seem to occur in the melanocytes of the choroid in these animals. It is postulated that all three pigmented eye tissues (iris, RPE, and choroid) of adult vertebrates form melanin granules in vivo. However, nothing is known about the amount of this turnover.

摘要

本文是对成年脊椎动物眼睛虹膜、脉络膜和视网膜色素上皮(RPE)中黑色素周转情况的已知信息综述。电子显微镜照片显示了脉络膜和视网膜色素上皮黑色素颗粒在大小和结构上的差异。在暴露于强光下的成年仓鼠的RPE中显示了黑色素合成的经典阶段,包括前黑素体。在这些动物的脉络膜黑素细胞中似乎也发生黑色素的降解或合成。据推测,成年脊椎动物的所有三种色素性眼组织(虹膜、RPE和脉络膜)在体内形成黑色素颗粒。然而,关于这种周转量尚不清楚。

相似文献

1
Does melanin turnover occur in the eyes of adult vertebrates?成年脊椎动物的眼睛中会发生黑色素周转吗?
Pigment Cell Res. 1993 Aug;6(4 Pt 1):193-204. doi: 10.1111/j.1600-0749.1993.tb00602.x.
2
Age-related melanogenesis in the eye of mice, studied by microautoradiography of 3H-methimazole, a specific marker of melanin synthesis.通过对黑色素合成的特异性标记物3H-甲巯咪唑进行显微放射自显影,研究小鼠眼中与年龄相关的黑色素生成。
Exp Eye Res. 1998 Sep;67(3):259-64. doi: 10.1006/exer.1998.0513.
3
Retinal pigment epithelial cells from Royal College of Surgeons dystrophic rats can take up melanin granules.来自皇家外科医学院营养不良大鼠的视网膜色素上皮细胞能够摄取黑色素颗粒。
Graefes Arch Clin Exp Ophthalmol. 1999 Jan;237(1):67-71. doi: 10.1007/s004170050196.
4
[Melanin granule metabolism in the iris and retinal pigment epithelium in adult tritions after completion of eye regeneration].[成年蝾螈眼睛再生完成后虹膜和视网膜色素上皮中的黑色素颗粒代谢]
Ontogenez. 1978;9(2):183-8.
5
X-ray microanalysis of melanin granules of retinal pigment epithelium and choroid in hereditary copper deficient mice (macular mice).遗传性铜缺乏小鼠(黄斑小鼠)视网膜色素上皮和脉络膜黑色素颗粒的X射线微分析
Exp Eye Res. 1999 Jan;68(1):59-65. doi: 10.1006/exer.1998.0592.
6
Photoprotection role of melanin in the human retinal pigment epithelium. Imaging techniques for retinal melanin.黑色素在人视网膜色素上皮中的光保护作用。视网膜黑色素的成像技术。
Rom J Ophthalmol. 2020 Apr-Jun;64(2):100-104.
7
Effect of eye pigmentation on transscleral drug delivery.眼色素沉着对经巩膜给药的影响。
Invest Ophthalmol Vis Sci. 2008 Jan;49(1):333-41. doi: 10.1167/iovs.07-0214.
8
Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium.倍他洛尔、美托洛尔与寡核苷酸与合成及牛眼黑色素的结合,以及对药物与人脉络膜视网膜色素上皮中黑色素结合的预测。
Pharm Res. 2007 Nov;24(11):2063-70. doi: 10.1007/s11095-007-9342-0. Epub 2007 Jun 2.
9
Drug Distribution to Retinal Pigment Epithelium: Studies on Melanin Binding, Cellular Kinetics, and Single Photon Emission Computed Tomography/Computed Tomography Imaging.药物向视网膜色素上皮的分布:黑色素结合、细胞动力学及单光子发射计算机断层扫描/计算机断层扫描成像研究
Mol Pharm. 2016 Sep 6;13(9):2977-86. doi: 10.1021/acs.molpharmaceut.5b00787. Epub 2016 Jan 27.
10
Melanin protects choroidal blood vessels against light toxicity.黑色素可保护脉络膜血管免受光毒性损伤。
Z Naturforsch C J Biosci. 2006 May-Jun;61(5-6):427-33. doi: 10.1515/znc-2006-5-620.

引用本文的文献

1
Specialised features of melanosomes in health and disease in the retinal pigment epithelium.视网膜色素上皮中黑素小体在健康与疾病中的特殊特征。
Front Cell Dev Biol. 2025 Sep 3;13:1593840. doi: 10.3389/fcell.2025.1593840. eCollection 2025.
2
Acetylcholine regulates the melanogenesis of retinal pigment epithelia cells via a cAMP-dependent pathway: A non-neuronal function of cholinergic system in retina.乙酰胆碱通过环磷酸腺苷(cAMP)依赖途径调节视网膜色素上皮细胞的黑色素生成:胆碱能系统在视网膜中的非神经元功能。
Heliyon. 2024 Aug 13;10(16):e36207. doi: 10.1016/j.heliyon.2024.e36207. eCollection 2024 Aug 30.
3
Vorolanib, sunitinib, and axitinib: A comparative study of vascular endothelial growth factor receptor inhibitors and their anti-angiogenic effects.
沃拉尼布、舒尼替尼和阿昔替尼:血管内皮生长因子受体抑制剂及其抗血管生成作用的比较研究。
PLoS One. 2024 Jun 4;19(6):e0304782. doi: 10.1371/journal.pone.0304782. eCollection 2024.
4
Catabolism of lysosome-related organelles in color-changing spiders supports intracellular turnover of pigments.变色蜘蛛溶酶体相关细胞器的分解代谢支持细胞内色素的周转。
Proc Natl Acad Sci U S A. 2021 Aug 31;118(35). doi: 10.1073/pnas.2103020118.
5
Three-Dimensional Distribution Of Fundus Depolarization and Associating Factors Measured Using Polarization-Sensitive Optical Coherence Tomography.基于偏振敏感光学相干断层扫描的眼底去极化三维分布及其相关因素的研究
Transl Vis Sci Technol. 2021 Feb 5;10(2):30. doi: 10.1167/tvst.10.2.30.
6
Ultrastructural alterations in the retinal pigment epithelium and photoreceptors of a Stargardt patient and three Stargardt mouse models: indication for the central role of RPE melanin in oxidative stress.一名Stargardt病患者及三种Stargardt小鼠模型的视网膜色素上皮和光感受器的超微结构改变:RPE黑色素在氧化应激中核心作用的指征
PeerJ. 2018 Jul 19;6:e5215. doi: 10.7717/peerj.5215. eCollection 2018.
7
Intrastriatal transplantation of retinal pigment epithelial cells for the treatment of Parkinson disease: in vivo longitudinal molecular imaging with 18F-P3BZA PET/CT.视网膜色素上皮细胞脑内纹状体移植治疗帕金森病:18F-P3BZA PET/CT活体纵向分子成像
Radiology. 2014 Jul;272(1):174-83. doi: 10.1148/radiol.14132042. Epub 2014 Apr 20.
8
AAV-mediated tyrosinase gene transfer restores melanogenesis and retinal function in a model of oculo-cutaneous albinism type I (OCA1).腺相关病毒介导的酪氨酸酶基因转移可恢复I型眼皮肤白化病(OCA1)模型中的黑素生成和视网膜功能。
Mol Ther. 2009 Aug;17(8):1347-54. doi: 10.1038/mt.2009.112. Epub 2009 May 12.
9
Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis.Rab38缺陷型视网膜色素上皮细胞中的黑素小体成熟缺陷导致短暂黑素生成过程中未成熟黑素小体的不稳定。
Mol Biol Cell. 2007 Oct;18(10):3914-27. doi: 10.1091/mbc.e07-03-0268. Epub 2007 Aug 1.
10
Reduced-illuminance autofluorescence imaging in ABCA4-associated retinal degenerations.ABCA4相关视网膜变性中的低照度自发荧光成像
J Opt Soc Am A Opt Image Sci Vis. 2007 May;24(5):1457-67. doi: 10.1364/josaa.24.001457.