Lawler J E, Naylor S K, Abel M M, Baldwin D R
Physiology Program, University of Tennessee, Knoxville 37996-0900.
Physiol Behav. 1993 Nov;54(5):941-6. doi: 10.1016/0031-9384(93)90306-z.
Both the human and animal literatures suggest that reactivity to stress is enhanced in the presence of a positive family history of hypertension. There is also some suggestive evidence, though not as strong, that a high-salt diet will enhance reactivity to stress, at least in a subpopulation of individuals. In the present study, rats with zero (Wistar-Kyoto, or WKY), one (borderline hypertensive, or BHR), or two (spontaneously hypertensive, or SHR) hypertensive parents were placed on a normal or high (8% in chow)-salt diet for 8 weeks starting at 8 weeks of age. After 6 weeks on the appropriate diet, rats were stressed daily for 5 days. Each session consisted of 28 foot shock trials preceded by a tone. On the following week, animals were instrumented with femoral artery catheters. After a 2-day recovery period, they were again subjected to the experimental paradigm, during which blood pressure was continuously monitored. Differences were found with respect to blood pressure reactivity and family history: SHR were the most reactive to the tone associated with foot shock. However, no effects of salt on reactivity were observed, despite an effect of this manipulation on basal blood pressure. The effect of foot shock itself was also studied, and revealed that BHR showed a blood pressure reactivity response intermediate between SHR and WKY. Once again, no effects of the salt manipulation were seen. In conclusion, while the data support a relationship between family history of hypertension and reactivity to stress, they do not support a relationship between salt intake and reactivity to stress.(ABSTRACT TRUNCATED AT 250 WORDS)
人类和动物研究文献均表明，在有高血压家族史的情况下，对应激的反应性会增强。也有一些提示性证据（尽管不那么有力）表明，高盐饮食会增强对应激的反应性，至少在部分个体亚群中如此。在本研究中，将具有零个（Wistar-Kyoto，即WKY）、一个（临界高血压，即BHR）或两个（自发性高血压，即SHR）高血压亲本的大鼠从8周龄开始置于正常或高盐（饲料中含8%）饮食中8周。在适当饮食6周后，大鼠每天接受应激处理，持续5天。每次处理包括28次先有音调提示的足部电击试验。在接下来的一周，给动物安装股动脉导管。经过2天的恢复期后，它们再次接受实验范式，在此期间持续监测血压。在血压反应性和家族史方面发现了差异：SHR对与足部电击相关的音调反应最为强烈。然而，尽管这种处理对基础血压有影响，但未观察到盐对反应性的影响。还研究了足部电击本身的影响，结果显示BHR的血压反应性介于SHR和WKY之间。同样，未发现盐处理的影响。总之，虽然数据支持高血压家族史与应激反应性之间的关系，但不支持盐摄入量与应激反应性之间的关系。（摘要截选至250词）
