Stackhouse M A, Bedford J S
Department of Radiological Health Sciences, Colorado State University, Fort Collins 80523.
Radiat Res. 1993 Nov;136(2):250-4.
An ionizing radiation-sensitive mutant of CHO cells, irs-20, irradiated in plateau-phase cultures showed a complete lack of a dose-rate effect, i.e., there was no reduction in cell killing per unit dose as the dose rate was lowered from 0.75 Gy/min to 0.06 Gy/h. No measurable repair of potentially lethal damage or sublethal damage was evident for irs-20 cells in the G1 phase of the cell cycle. During S phase, irs-20 cells showed repair of sublethal damage similar to that for the wild-type cells.
在平台期培养中接受辐照的中国仓鼠卵巢（CHO）细胞的一种电离辐射敏感突变体irs-20，表现出完全缺乏剂量率效应，即当剂量率从0.75 Gy/分钟降至0.06 Gy/小时时，单位剂量的细胞杀伤没有减少。对于处于细胞周期G1期的irs-20细胞，未观察到潜在致死损伤或亚致死损伤的可测量修复。在S期，irs-20细胞表现出与野生型细胞类似的亚致死损伤修复。
