Castillo A, Valderrama G, Ardiles L, Caorsi I, Mezzano S
Unidad de Nefrología, Facultad de Medicina, Universidad Austral de Chile, Valdivia.
Rev Med Chil. 1993 Mar;121(3):260-4.
Antineutrophil cytoplasmic autoantibodies (ANCA), are serologic markers of disease in rapidly progressive glomerulonephritis without immune deposits (pauci-immune) and vasculitis, and could play a pathogenic role in these diseases. We communicate 5 patients with pauci-immune rapidly progressive glomerulonephritis; four of them in the evolution of necrotizing systemic vasculitis (Wegener's granulomatosis and microscopic polyarteritis) and one case with lesions limited to the kidney. All of them were associated with the presence of ANCA. The immunofluorescence pattern (cytoplasmic and perinuclear) and the antigenic specificity of ELISA assay, [antiproteinase-3 (PR-3) and antimyeloperoxidase (MOP)], are useful laboratory tools for the diagnosis and clinical management of these patients.
抗中性粒细胞胞浆自身抗体（ANCA）是无免疫沉积物（少免疫性）的快速进行性肾小球肾炎和血管炎的疾病血清学标志物，并且可能在这些疾病中发挥致病作用。我们报告5例少免疫性快速进行性肾小球肾炎患者；其中4例处于坏死性系统性血管炎（韦格纳肉芽肿病和显微镜下多动脉炎）进展期，1例病变局限于肾脏。所有患者均伴有ANCA。免疫荧光模式（胞浆型和核周型）以及酶联免疫吸附测定（ELISA）的抗原特异性[抗蛋白酶-3（PR-3）和抗髓过氧化物酶（MOP）]，是这些患者诊断和临床管理的有用实验室工具。
