8至9岁儿童龈沟液中的组织型纤溶酶原激活剂（t-PA）和胎盘纤溶酶原激活剂抑制剂（PAI-2）

Tissue plasminogen activator (t-PA) and placental plasminogen activator inhibitor (PAI-2) in gingival fluid from 8-9-year-old children.

作者信息

Kinnby B, Borgström M K, Granath L, Lecander I, Sundin B

机构信息

Department of Pedodontics, Lund University, School of Dentistry, Malmö, Sweden.

出版信息

Scand J Dent Res. 1993 Oct;101(5):279-81. doi: 10.1111/j.1600-0722.1993.tb01120.x.

DOI:10.1111/j.1600-0722.1993.tb01120.x

PMID:8248729

Abstract

High concentrations of tissue plasminogen activator (t-PA) and placental type plasminogen activator inhibitor (PAI-2) have previously been found in gingival crevicular fluid (GCF) of adults. In the present study, the levels were examined in 16 children aged 8-9 yr. Sampling of GCF was performed with small disks of Millipore-filter. t-PA and PAI-2 were analyzed with enzyme-linked immunosorbent assays with low method errors. The mean concentration of t-PA was slightly higher than in adults, while the mean PAI-2-concentration was slightly lower. An intraindividual study comparing healthy and inflamed sites in the children showed slightly higher concentrations in GCF from inflamed sites. No change was observed in the balance between t-PA and PAI-2.

摘要

此前已发现，成人龈沟液（GCF）中存在高浓度的组织型纤溶酶原激活物（t-PA）和胎盘型纤溶酶原激活物抑制剂（PAI-2）。在本研究中，对16名8至9岁儿童的这些水平进行了检测。使用密理博滤膜小圆盘对GCF进行采样。采用酶联免疫吸附测定法分析t-PA和PAI-2，方法误差较低。t-PA的平均浓度略高于成人，而PAI-2的平均浓度略低。一项比较儿童健康部位和炎症部位的个体内研究显示，炎症部位GCF中的浓度略高。t-PA和PAI-2之间的平衡未观察到变化。