García-Dorado A
Departamento de Genética, Universidad Complutense, Madrid, Spain.
Theor Popul Biol. 1993 Oct;44(2):177-88. doi: 10.1006/tpbi.1993.1024.
We derive analytical predictions for the variance and kurtosis of the equilibrium distribution of allelic effects under stabilizing selection and drift, and for any value of the kurtosis of the distribution of the mutational effects. Numerical results relative to the equilibrium genetic variance are compared with other analytical predictions and with simulation results from the literature. Our prediction is superior for relatively weak selection (or relatively low variance of the mutational effects) and not to small population sizes, where previous methods overestimate the equilibrium genetic variance. The behavior of the equilibrium kurtosis is also illustrated.
我们推导了在稳定选择和漂变作用下,等位基因效应平衡分布的方差和峰度的解析预测值,适用于突变效应分布的任何峰度值。将与平衡遗传方差相关的数值结果与其他解析预测值以及文献中的模拟结果进行了比较。在选择相对较弱(或突变效应的方差相对较低)且种群大小不过小的情况下,我们的预测更为优越,而之前的方法会高估平衡遗传方差。同时还展示了平衡峰度的行为。