Kohn B, Guscetti F, Waxenberger M, Augsburger H
Veterinär-Medizinischen Klinik, Universität Zürich.
Tierarztl Prax. 1993 Oct;21(5):451-7.
A case of muscular dystrophy in a 1-year-old male castrated Domestic Shorthair cat is presented. The most striking clinical features were regurgitation, a stiff gait, an increased muscle tone and exercise intolerance. Serum biochemistry panels showed a marked increase in the muscle specific enzyme creatine kinase, and moderately elevated levels of LDH, AST and ALT. Spontaneous electrical activity of skeletal muscles in the form of "bizarre high frequency discharges" and "myotonia-like repetitive discharges" were registered. Gross pathology revealed a marked hypertrophy of the skeletal muscles. The main histopathological changes were myofiber necrosis and calcification, variation in fiber size, hypertrophied muscle fibers of type I and type II and fiber splitting. Indirect immunofluorescence showed dystrophin deficiency. Feline muscular dystrophy resembles the X-linked human Duchenne muscular dystrophy (DMD). Besides the X-linked muscular dystrophy in the mouse and Golden Retriever the feline muscular dystrophy could represent another valuable animal model for the study of DMD.
本文报告了一例1岁去势家养短毛雄性猫的肌肉萎缩症。最显著的临床特征为反流、步态僵硬、肌张力增加和运动不耐受。血清生化检查显示肌肉特异性酶肌酸激酶显著升高，乳酸脱氢酶、天冬氨酸转氨酶和丙氨酸转氨酶水平中度升高。记录到骨骼肌以“奇异高频放电”和“肌强直样重复放电”形式出现的自发电活动。大体病理学显示骨骼肌明显肥大。主要组织病理学变化为肌纤维坏死和钙化、纤维大小变异、I型和II型肌纤维肥大以及纤维分裂。间接免疫荧光显示肌营养不良蛋白缺乏。猫肌肉萎缩症类似于X连锁的人类杜兴氏肌肉萎缩症（DMD）。除了小鼠和金毛寻回犬中的X连锁肌肉萎缩症外，猫肌肉萎缩症可能是研究DMD的另一个有价值的动物模型。
