Adamson R E, Hernandez A G, Chance M L, Bonfante-Garrido R, Maingon R D
Liverpool School of Tropical Medicine, Merseyside, UK.
Trans R Soc Trop Med Hyg. 1993 Jul-Aug;87(4):484-8. doi: 10.1016/0035-9203(93)90051-q.
Studies of cutaneous leishmaniasis in 3 endemic foci in Tachira state, western Venezuela have revealed sympatric populations of parasites causing both cutaneous and mucocutaneous disease. Immunological techniques and measurement of protease/acid phosphatase activities have been used to detect species-specific parasite antigens from 3 isolates from Tachira. Identified antigens of particular interest had molecular masses of 100, 82, 66, 50 and 27 kDa, but there was a high degree of heterogeneity between the antigens of the Tachira isolates and other Venezuelan strains of Leishmania braziliensis and L. mexicana. This heterogeneity has implications concerning the selection of antigens for use in serodiagnosis of leishmaniasis.
对委内瑞拉西部塔奇拉州3个地方病疫源地的皮肤利什曼病研究发现，导致皮肤和黏膜皮肤疾病的寄生虫同域种群。免疫技术以及蛋白酶/酸性磷酸酶活性测定已用于检测来自塔奇拉的3个分离株的种特异性寄生虫抗原。特别感兴趣的已鉴定抗原有100、82、66、50和27 kDa的分子量，但塔奇拉分离株的抗原与巴西利什曼原虫和墨西哥利什曼原虫的其他委内瑞拉菌株之间存在高度异质性。这种异质性对利什曼病血清诊断中抗原的选择具有影响。
